Abstract: This work is based on the manifold-embedding approach to study biological molecules exhibiting continuous conformational changes. Previous work established a method—now termed ...
Intrinsically Disordered Proteins (IDPs) challenge traditional structure-function paradigms by existing as dynamic ensembles rather than stable tertiary structures. Capturing these ensembles is ...
Predicting protein conformational changes remains a crucial challenge in computational biology and artificial intelligence. Breakthroughs achieved by deep learning, such as AlphaFold2, have moved the ...
Researchers at Tokyo Institute of Technology for the first time discovered the selective generation of three types of structural isomers (a set of different nanostructures with an identical chemical ...
Thalidomide, one of the most infamous drugs of all, caused severe birth defects in the children of pregnant women who took the drug for nausea in the 1950s. Its story has been repeated over and over – ...
Sajish Mathew receives funding from NIH COBRE grant (P20GM109091). The effects a drug or chemical compound have on the body depend on how its atoms are arranged in space. Some compounds have a dark ...
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